Age-Defying Treatment
with Hydroxy Acids & Retinol


Stimulate & Renew

A blend of Microencapsulated Retinol and AHAs encourage skin renewal to reduce the appearance of wrinkles and imperfections while evening skin tone. This rich, exfoliating and multitasking cream gently resurfaces and hydrates the skin. Define exfoli¬ates multiple layers of the skin while delivering 2% AGP Complex deep into the skin.

  • Benefits
  • Application
  • Ingredients


A combination of science and botanical ingredients help firm skin and smooth lines and wrinkles.

Conditioning moisturizers help attract and retain vital moisture in the skin.

Helps to even skin tone by reducing the look of acne scars, dark spots and hyper-pigmentation.

Free radical-fighting antioxidants defend skin from environmental stress that can cause inflammation and damage to collagen and elastin.

Acne is caused when oil, hair and dead skin cells clog pores. Ingredients such as Salicylic Acid and AGP Complex help stimulate cell turnover to curb breakouts.

Improved texture and proper product absorption is due to exfoliation. When the surface layer of the skin is removed, fresh skin is revealed and can absorb active ingredients easier.

AGP Complex – a microencapsulated retinol for oily, congested and acne-prone skin – encourages skin renewal to reduce the appearance of wrinkles and imperfections.

For those with severe gluten sensitivities or Dermatitis Herpetiformis, rest assured this product is gluten free.



Apply a small amount to freshly cleansed and toned skin 2-4 times weekly as part of your nightly regimen. Use as tolerated. Follow with a moisturizer if further hydration is needed.


Apply a small amount to freshly cleansed and toned skin 2-4 times weekly as part of your nightly regimen. Use as tolerated. Follow with a moisturizer if further hydration is needed.


All Ingredients

Key Ingredients
Microencapsulated Retinol Complex l The gold standard in age defiance
Chirally Correct L-Lactic Acid, L-Malic Acid, L-Tartaric Acid I A triple hydroxy acid cocktail that gently exfoliates while revealing the look of smoother even-toned skin

Aqua (Water), Lactic Acid (L), Glyceryl Stearate, Glycerin, Albumen, Retinol, Cetyl Alcohol, Stearic Acid, Malic Acid (L), Tartaric Acid (L), Hamamelis Virginiana (Witch Hazel) Water, Olea Europaea (Olive) Fruit Oil, D-alpha-tocopherol, Aloe Barbadensis Leaf Juice, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Galactoarabinan, Allantoin, Lecithin, Bisabolol (L-alpha), Benzyl Alcohol, Fullersomes, Citrus Grandis (Grapefruit) Peel Oil, Cananga Odorata Flower Oil, Prunus Persica (Peach) Kernel Oil




Purity Clean

Exfoliating Cleanser





Age-Defying Treatment
with Hydroxy Acids & Retinol




Purity Balance

Exfoliating Prep Toner

  • Reviews
  • Q&A


Define is rated 4.733333333333333 out of 5 by 30.
Rated 4 out of 5 by from Great product I began using define in conjunction with hydrate+ and purity face wash after I had gotten terrible hormonal acne from going off birth control. I was prescribed spironolacetone by a dermatologist to help clear my skin but I was left with some superficial scars that were bothersome. My experience: I had excessive dryness about 2 weeks after I began using, so I stopped for a few days and once I started applying again, I haven't had any more issues. As everyone else mentioned, it does tingle and sometimes I feel slight discomfort for about 5 min. It's overall a great product and I feel it's worth the money because it actually works!
Date published: 2015-06-10
Rated 4 out of 5 by from Incredible! I was totally new to any type of retin-a product and my esthetician recommended this to address some wrinkles I started to develope on my chest. (Yes...I was a sunworshipper who grew up in sunny California in the 70's...who thought SPF was uncool!) I was surprised at what a difference it made...especially to the texture of my skin. It became like that of a baby. Seriously! I would just sit and pet my skin. It didn't make my wrinkles disappear...however, it did make them appear less deep. As with any product you do have to be consistent. I will say that a little goes a long it IS retin-a and is powerful. I've made the mistake and slathered it on a little too thick and felt the wrath for a good 2 weeks.
Date published: 2011-05-12
Rated 5 out of 5 by from My beauty secret I was recommended Cosmedix Define by my dermatologist. I had adult acne, pigmented scars and my skin was dry from using harsh products.I have been using Define for 4+ years and my skin is clear of scars, visibly supple and youthful. I saw results within the first 2 weeks of use.I have next to no breakouts and my skin tone is even and smooth.Define is great value and one jar lasts me 12+ months. I apply very sparingly at night and always wear sunscreen - as my skin becomes more UV sensitive with this product.I cannot recommend Define highly enough.
Date published: 2012-01-26
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How big is it? and is it for eye area or not?

Asked by: Anna
The Define is 1.5 oz and it is not recommended for the eye area.
Answered by: CosMedix
Date published: 2016-09-27

What is the difference between this Define and Defy? I'm so confused. I'm using Defy right now.

Asked by: Asian
Defy and Define are basically the same product, an AHA treatment for your skin. However, Define has 2% encapsulated retinol added to it for further cell regeneration.
Answered by: East Coast Educator
Date published: 2016-07-20

What do you recommend using with this product for extremely acne prone skin with scarring?

Asked by: Nina
Two great partner products would be Clarity Serum, which is our Benzoyl Peroxide free acne serum and I would also recommend our Clear Mask, which helps to decongest and clear up breakouts. If your skin is responding well to the Define, you could next step up to our 4% Retinol product, Refine which has a more liquid base and is great for oilier skin. Start by applying every other day and if no irritation or redness occurs, apply daily.
Answered by: East Coast Educator
Date published: 2016-07-20
  • 2016-10-26T10:01CST
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