Micro Defense Microbiome Sheet Mask set shown with outer box and a single sheet mask
Close-up of a white sheet mask against a textured fabric background
Close-up view of bubble wrap texture in soft gray tones
Three Micro Defense sheet mask sachets with blue abstract packaging laid out
CosMedix Micro Defense Microbiome Sheet Mask packaging with blue gray abstract artwork on a white border
Micro Defense Microbiome Sheet Mask set shown with outer box and a single sheet mask
Close-up of a white sheet mask against a textured fabric background
Close-up view of bubble wrap texture in soft gray tones
Three Micro Defense sheet mask sachets with blue abstract packaging laid out
CosMedix Micro Defense Microbiome Sheet Mask packaging with blue gray abstract artwork on a white border

25% OFF APPLIED IN CART

-- Days
-- Hours
-- Minutes
-- Seconds

Micro Defense Microbiome Sheet Mask Set, 5-pcs

$61.00

Sheet Mask AM/PM

Micro Defense Microbiome Sheet Mask is a complexion-quenching peel off face mask that deeply hydrates the skin with a moisture-rich prebiotic serum, a good bacteria-boosting serum, that helps strengthen your skin’s natural defense for a softer, smoother, more supple-looking complexion.

This luxe, rejuvenating face mask helps replenish the surface of dry or dull skin, often damaged by outside stressors, for a healthier, more radiant and balanced-looking complexion. Featuring skin-plumping sodium hyaluronate and nourishing almond and coconut oils, this luxe, 5-piece sheet mask set reduces the appearance of fine lines and wrinkles and helps restore beneficial flora in the skin, which aids in protection from environmental stressors.

0.7 fl oz/ 20mL each

Build Your Routine
Cosmedix Cell ID Nutritive Defense Serum bottle on a white background

Achetez-le avec

Cell ID Nutritive Defense Serum

$128.00

Achat rapide  
Cosmedix Peptide Rich Defense skincare product on a white background

Achetez-le avec

Peptide Rich Defense SPF 50

$64.00

Achat rapide  
  • Reduces the look of fine lines and wrinkles
  • Quenches dry skin with moisture-locking hydration
  • Helps reduce the look of redness and soothes skin

In-clinic treatments or daily cleansing routines can quietly disrupt the balance of your skin’s microbiome, leaving the barrier vulnerable. The Micro Defense Microbiome Sheet Mask is a microbiome hydrating sheet mask designed to restore that balance while delivering immediate comfort to skin that feels sensitized.

This is not just a hydrating sheet mask, but is designed to support the skin’s natural defense system, helping reinforce barrier resilience at a time when it is most susceptible to stress. The serum infusion works to replenish moisture while encouraging a healthier microbiome environment, allowing skin to recalibrate rather than simply masking dryness.

After treatments that challenge the skin, including exfoliation or resurfacing, the barrier often needs structured support, and this post-procedure sheet mask delivers lightweight hydration that absorbs evenly. This helps reduce the feeling of tightness while promoting a more stable surface. Skin feels cooled and visibly less reactive after use.

The sheet adheres closely to the contours of the face, ensuring consistent delivery across areas that tend to dry out faster. This allows active ingredients to penetrate without disruption, which supports uniform hydration and skin barrier strengthening. The Micro Defense Microbiome Sheet Mask fits easily into both clinical recovery routines and at-home maintenance.

Apply the mask to clean skin and leave it on for around 10 to 15 minutes. Once removed, press the remaining serum into the skin using gentle upward motions. There is no need to rinse. Follow with a moisturizer suited to your skin condition to seal in hydration and reinforce barrier support.

With consistent use, your skin should feel more resilient, less dry, and better hydrated throughout the day.

AM - Remove sheet mask from package and gently peel away the protective mesh layer. Position mask over clean, dry skin. Smooth to fit the curves of the face, adjusting around the eyes, nose and mouth. Leave on skin for 15 minutes. Remove and lightly massage the remaining serum over the face, neck and décolleté, gently patting in with your fingertips. Follow with your favorite daytime serum and sunscreen.

PM - Remove sheet mask from package and gently peel away the protective mesh layer. Position mask over clean, dry skin. Smooth to fit the curves of the face, adjusting around the eyes, nose and mouth. Leave on skin for 15 minutes. Remove and lightly massage the remaining serum over the face, neck and décolleté, gently patting in with your fingertips. Follow with your favorite nighttime serum and moisturizer if needed.

1. What makes the Micro Defense Microbiome Sheet Mask different from a regular hydrating sheet mask?

Most hydrating and skin barrier-strengthening masks focus only on adding moisture to the surface. The Micro Defense Microbiome Sheet Mask goes further by supporting the microbiome, which plays a central role in how well the skin barrier functions. This improves hydration while actively contributing to skin barrier strengthening.

2. Is this suitable as a post-procedure sheet mask?

Yes, this formula is especially well-suited for post-procedure use, as after treatments, skin often becomes reactive and loses moisture quickly. This sheet mask delivers calming hydration, helping restore comfort while supporting recovery. It also integrates easily into professional aftercare routines.

3. How often should I use a microbiome hydrating sheet mask?

Frequency depends on your skin condition. For maintenance, one to three times per week generally works well. If your skin is recovering from a treatment or feels particularly compromised, it can be used more frequently to support ongoing hydration.

4. Will this help with sensitive skin?

Sensitivity is often a sign of barrier disruption rather than a fixed skin type. The Micro Defense Microbiome Sheet Mask supports the microbiome and reinforces the barrier, helping reduce visible reactivity.

5. Do I need to rinse after using the mask?

No, rinsing is not necessary, as the remaining serum is designed to absorb into the skin. Just press it in gently after removing the mask, then follow with your moisturizer to lock in hydration.

6. Can this be used alongside other Cosmedix treatments?

Yes, it pairs particularly well with barrier-supportive moisturizers and gentle cleansers. It is often used before finishing products to enhance hydration and improve overall product absorption.

7. How quickly will I see results?

Immediate results include improved hydration and a more comfortable skin feel. Your skin looks calmer and more refreshed after a single use, and with consistent application, you may notice stronger barrier performance and reduced dryness within a few weeks.

8. Is this only for post-treatment use?

While it excels as a post-procedure sheet mask, it is equally effective as part of a regular skincare routine. Use it as a weekly reset for stressed skin or as a targeted support whenever hydration feels compromised.

AM/PM Use
Towelette
Dry et All skin types

Benefits & Usage

Botanical Hero

Botanical Hero

Cocos Nucifera (Coconut) Oil

Hydrating skin conditioner, rich in antioxidants

Young woman with clear skin holds a white sheet mask near her face ready to apply

How to Apply

AM - Remove sheet mask from package and gently peel away the protective mesh layer. Position mask over clean, dry skin. Smooth to fit the curves of the face, adjusting around the eyes, nose and mouth. Leave on skin for 15 minutes. Remove and lightly massage the remaining serum over the face, neck and décolleté, gently patting in with your fingertips. Follow with your favorite daytime serum and sunscreen.

PM - Remove sheet mask from package and gently peel away the protective mesh layer. Position mask over clean, dry skin. Smooth to fit the curves of the face, adjusting around the eyes, nose and mouth. Leave on skin for 15 minutes. Remove and lightly massage the remaining serum over the face, neck and décolleté, gently patting in with your fingertips. Follow with your favorite nighttime serum and moisturizer if needed.

Transformative Ingredients

Clean. Clinical. Luxurious

Clinically Proven Efficacy

  • Boosts moisture levels in skin for the look of plumper, more supple skin

  • Soothes and replenishes skin

  • Powerful prebiotic helps support natural skin defenses

  • You May Also Like
  • Recently viewed

Customers said this hydrating sheet mask delivers "glowy and bright skin" with "fantastic hydration." Most praised the smooth, supple results and calming effect. However, some felt results were "underwhelming" for the price, noting the serum absorbs slowly and benefits are fleeting. The mask has a mild scent that may irritate sensitive skin.

  • I woke up with such glowy and bright skin!!!
  • Love how hydrated and plump my skin feels after use
  • My skin was so supple, glowy, and fresh.
Moisture (positive)Serum (positive)Glow (positive)Mask (positive)Hydration (positive)
  • 5 stars: 62 (93%)
  • 4 stars: 3 (4%)
  • 3 stars: 2 (3%)
  • 2 stars: 0 (0%)
  • 1 star: 0 (0%)
m
madsen
Amazing

Great mask

J
Jo228
Recommend To a Friend: No
age: 25 to 39 years old
Value 1 = Poor Value, 5 = Excellent Value: 2
Quality 1 = low, 5 = high: 4
Not Worth The Price

This sheet mask is, unfortunately, one of those products that looks and sounds luxurious but doesn't deliver enough to justify the high price tag. For something marketed as a microbiome-boosting, deeply hydrating treatment, the results feel pretty underwhelming. The serum it comes soaked in is average at best�it provides some basic hydration, but nothing that feels transformative or long-lasting. It doesn't absorb particularly well, and while it's not irritating, it also doesn't leave the skin noticeably plumper or more radiant than a standard hydrating mask might.

The texture of the actual sheet mask is fine�it fits well enough, and the material feels decent on the skin, but again, nothing about it feels exceptional or indulgent considering the price. It holds the serum without dripping, and it does stay in place during the 15-minute wear time, which is a plus. However, when you remove it and pat in the leftover essence, the skin feels only mildly refreshed. The softness and smoothness claimed by the brand are fleeting, and the “microbiome support” is hard to detect or feel any real benefit from.

The included ingredients like coconut oil and sodium hyaluronate sound promising, and while they may have some benefit, they aren't doing anything extraordinary here that you couldn't get from more affordable alternatives. In fact, there are plenty of drugstore sheet masks that perform similarly�if not better�for a fraction of the cost.

Overall, this feels more like a treat you'd gift someone than a serious skincare essential. It's not a bad product, but it simply doesn't live up to its price or marketing claims. If you're looking for deep hydration or visible results, your money would be better spent on a high-quality serum or moisturizer that lasts more than 15 minutes on your face.

c
chansi
Amazing

Love this product. It's amazing.

c
crenee
Amazing

Love this product. It's amazing.

T
Tara J.
age: 40 to 60 years old
Value 1 = Poor Value, 5 = Excellent Value: 4
Quality 1 = low, 5 = high: 5
Love

Love how hydrated and plump my skin feels after use

k
kayla705
Recommend To a Friend: Yes
age: 25 to 39 years old
Value 1 = Poor Value, 5 = Excellent Value: 5
Quality 1 = low, 5 = high: 5
Best Mask I've Ever Tried

I got these as a gift and WOW! I just did a mask after a shower and then after removing the mask I rubbed the remaining serum in and let it set before following with my normal moisturizer. I woke up with such glowy and bright skin!!! Love these.

N
Naih
Recommend To a Friend: Yes
Value 1 = Poor Value, 5 = Excellent Value: 4
Quality 1 = low, 5 = high: 5
Powerful Results

I absolutely LOVE this product! It Does exactly what it says it's supposed to do! 10/10 recommendation!

L
LK
Recommend To a Friend: Yes
age: 25 to 39 years old
Value 1 = Poor Value, 5 = Excellent Value: 5
Quality 1 = low, 5 = high: 5
Hydrating masks

Loving these masks. Very calming and hydrating. Great post micro needling. Definitely ordering more when I run out.

a
alexis
Amazing Product

Amazing product.

J
Jean B.
Wonderful product! Love the way

Wonderful product! Love the way my skin feels after

J
Julie K.
The best mask!

Tried one for the first time last night as it came with my order as a sample and I'm loving it! I love that it comes with a sheer insert so the mask doesn't stick together. Love the mild scent and it felt amazing and refreshing! Definitely going to order more!

K
Kateryna T.
Favourite new masks

Tried my first Cosmedix product because of Causebox and absolutely loved it. With this purchase I ordered a few different products which I am very much looking forward to trying.

K
Katherine B.
Like butter!

This was a luxurious treat. I did not expect much but was very pleased. Activating, my skin slightly tingled then felt firmed and quenched. In the end my face felt like butter, but also tight. I think it would be best used in the am before makeup application.

D
Deborah M.
Absolutely My FAV!

This sheet mask it's SUPER! Easy to apply, super rich and full of nutrients. Love the scent, so sweet! My skin is now hydrated and glowing!

J
Jessie E.
Game Changer!

This sheet mask is pure goodness!!! I originally received this as a free gift and was so in awe of it's results, I had to purchase them! This masks leaves my face so smooth and moisturized. I don't typically use sheet masks but this one hits - Highly recommend!

A
Anam M.
Super hydrating

This sheet mask was such a great hydrating product. It felt so relaxing after a day out in the cold winter winds. Loved how supple and glowy my skin looked after I used this mask. Can't say enough good things, will definitely be repurchasing once I run out!

D
Donna L.
Sample

This product was included in my order as a sample
I usually don't do mask like this
To my surprise it made a difference in my skin after only one use
Texture and overall appearance very happy with

K
Kara P.
Retinol uglies soother

This mask was very soothing and hydrating. So nice in starting a retinol.

E
Erin
These face masks are amazing!

These face masks are amazing! The Quality is futuristic. I got one as a sample and now I'm hooked. After I use this product my face is instantly Hydrated it looks and feels amazing. It looks younger and healthy. It's a must have! For the summer months . you get more than enough in one box . I highly recommend this amazing product

K
Kiara P.
Must try this sheet mask!

The sheet mask was amazing. Made my face feel super smooth and feel great. I noticed a different immediately.

D
Diane k.
really amazing tightening effect on

really amazing tightening effect on undereyes and general skin texture

C
Carrie F.
Nice and moisturizing! Loved it

Nice and moisturizing! Loved it and will purchase again!

O
Ondra P.
Love It

My wife loved this as her stocking stuffer.

A
Andrea V.
My skin was so smooth,

My skin was so smooth, very nice glow!

T
Theresa D.
MICROBIOME SHEET MASK

MICROBIOME SHEET MASK

B
Bryant T.
Love!

Love!

J
Jenny D.
Love your products!

Love your products!

P
Paula T.
Love this product! So soothing

Love this product! So soothing and fantastic hydration!

C
Ceylan D.
Love this mask

Love this mask

S
Suyyyrr
Great for the Winter!

Love the packaging and the texture of the sheet mask. My skin feels so moisturized after use. It has a scent to it which may cause irritation to sensitive skin, but fine with me.

L
Linda P.
Love it! Feels great

Love it! Feels great

Free Shipping

on all order over $160

Free Returns

within 30 days of purchase

#1 Spa Recommended

by Aestehticians & Dermatologists