Clean. Clinical. Luxurious.
TRANSFORMATIVE INGREDIENTS
Clinically Proven Efficacy.
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Pepoxide is an Antioxidant Peptide Concentrate multivitamin serum featuring 16 antioxidants and a potent Peptide to help address visible signs of aging, like uneven skin tone, fine lines, and wrinkles.
1 fl oz. / 30 mL
Daily exposure to environmental stress and oxidative damage slowly weakens how your skin functions. Pepoxide is designed to intervene as a hydrating anti-aging antioxidant serum that delivers targeted support through a refined blend of peptides and protective actives. These help defend and visibly improve skin clarity after daily stress or in post-procedure phases.
It has short-chain amino acids that work as messengers within the skin, helping support the look of firmness. When the skin has been compromised, this signal-based support becomes essential in helping guide the skin back toward balance.
What gives Pepoxide its distinct edge is how it combines peptide technology with antioxidant defense; the formula addresses free radical damage while maintaining hydration levels, which is critical when your skin is sensitive.
The texture is lightweight and silky, allowing it to integrate seamlessly into both clinical and homecare routines. As it absorbs quickly without leaving residue, it is suitable for layering with other treatments. This is important for building routines that prioritize recovery.
The product also works as a daily hydrating, anti-aging peptide serum, improving the visible effects of oxidative stress, and fitting naturally into a post-procedure brightening serum routine.
Use one to two pumps after cleansing and toning, then gently press into the skin, starting from the forehead and moving downward.
In the morning, follow with a moisturizer and SPF. In the evening, pair with a barrier-supporting moisturizer.
1. What makes Pepoxide different from a standard antioxidant serum?
Most antioxidant serums focus on a single pathway, such as free radical neutralization, while Pepoxide combines antioxidant protection with peptides that actively support skin communication and repair response. This dual mechanism allows it to function as a hydrating anti-aging antioxidant serum and a peptide serum at the same time.
2. Is Pepoxide suitable for post-procedure use?
Yes, Pepoxide is designed with a barrier-first philosophy. After professional treatments, skin often needs hydration, antioxidant support, and gentle reinforcement. This serum fits well into post-procedure routines because it supports recovery without introducing unnecessary stress.
3. Will it help with dull or uneven-looking skin?
While Pepoxide is not positioned as an aggressive brightening solution, its antioxidant system helps reduce the visible impact of environmental stress, which often contributes to dullness.
4. Can I use it with other active treatments?
Yes, Pepoxide’s lightweight texture allows it to sit comfortably under moisturizers, SPF, or targeted treatments. It is particularly effective when combined with a routine that includes gentle exfoliation and barrier-supporting hydration.
5. How often should I use it?
Pepoxide can be used both in the morning and the evening. Consistency matters more than intensity. Regular use allows the peptide and antioxidant systems to work gradually, supporting visible improvements in texture and tone.
6. Is this a good choice for sensitive or reactive skin?
Yes, it is, as the formulation avoids unnecessary irritation and focuses on supporting the skin barrier. This makes it suitable for individuals who experience sensitivity or are recovering from skin stress. Despite this, a patch test is still recommended.
7. What results should I expect over time?
In the early stages, skin often feels more hydrated and balanced. With continued use, there is a visible improvement in overall skin quality. Fine lines may be less apparent as the skin is supported at a structural level.
8. How does Pepoxide fit into a full Cosmedix routine?
Pepoxide works well as a foundational treatment step; pair it with a gentle cleanser such as Crystal Cleanse, follow with a moisturizer suited to your skin type, and always include SPF during the day. It also complements both brightening serums and controlled retinol use, helping maintain balance while other actives target specific concerns.
Aqua/Water/Eau, Alcohol Denat., Glycerin, Cocos Nucifera (Coconut) Fruit Juice, Hydrolyzed Collagen, Mannitol, Gluconolactone, Caffeine, Superoxide Dismutase, Phenyl T-Butylnitrone (Spin Trap), Waltheria Indica Leaf Extract, Glutathione (L), Hamamelis Virginiana (Witch Hazel) Water, Polygonum Cuspidatum (Giant Knotweed) Extract, Silybum Marianum (Milk Thistle) Extract, Acetyl Hexapeptide-1, Dextran, Citrus Paradisi (White Grapefruit) Peel Oil, Cupressus Sempervirens (Cypress) Leaf/Nut/Stem Oil, Totarol, Xanthan Gum, Sodium Gluconate, Sodium Benzoate, Potassium Sorbate, Sodium Hydroxide, Polysorbate 20, Citric Acid, Sodium Citrate, Acetyl Tributyl Citrate, Astaxanthin, Quercetin, Dextrin, Ferulic Acid, Alcohol, Isopropyl Alcohol, Calcium Gluconate.
Hydrolyzed Collagen - Locks in hydration for firmer-looking skin
A water-based serum that feels light and refreshing, with a smooth, fluid texture that spreads easily over the skin.
AM - Dispense one to two pumps of serum and apply to freshly cleansed and toned skin.
PM - Dispense one to two pumps of serum and apply to freshly cleansed and toned skin.
Clean. Clinical. Luxurious.
TRANSFORMATIVE INGREDIENTS
Clinically Proven Efficacy.
COSMEDIX Elite
PRE & POST POCEDURE SUPPORT
COSMEDIX® ELITE is designed to enhance all advanced skin procedures, allowing dermatologists and aestheticians to minimize procedure side effects while maximizing results.
Every treatment from chemical peels to ablative laser procedures can have improved healing time and better results when combined with our PREP and RECOVERY programs.
Pepoxide Antioxidant Peptide Concentrate
This program should be used daily and start two weeks
prior to the scheduled ablative treatment. All four formulas work together to maximize the skin’s ability to accept additional key ingredients and minimize the
risk of post-procedure redness and other discoloration.
This program is most beneficial when started within 24 to 48 hours of receiving the scheduled ablative treatment. The daily regimen will help to minimize the client’s recovery time by supplying the compromised skin with potent antioxidants and soothing ingredients. It will help replenish the skin’s moisture barrier and help protect against environmental stressors.
Customers praised this antioxidant peptide concentrate featuring 16 antioxidants for its lightweight texture that absorbs quickly. Many reported brighter, firmer skin with reduced fine lines and even tone. However, some noted the scent can be strong or medicinal, and texture may feel sticky initially though it layers well with other products.
Love the extra care
I got this is a sample to try and I've never really used anything like it before they except for one other brand and what I thought was weird about this one is this it was a little bit thicker than the second it hit your skin it was almost a little cooling and went watery and then your skin just soaks it in I thought that was quite strange But there is no denying that it does work and I'm definitely getting a lot of the scars lifting off my face from sun and exposure that being said it has a ton of different stuff in it but like see I think b and it's coconut water-based that's probably why it's cooling
I loved this serum. This was my first introduction to this brand and I have been wanting to try antioxidants for quite some time. This serum is wonderful and didn't irritate my skin barrier at all. You can tell it is antioxidant rich immediately from its dark orange shade,its natural but light scent that fades away immediately,and the way it sinks right into my skin. It left my face glowing each time I used it and I realized after the first use that 1 pump is all I needed to with these products as they are highly potent and effective with not much needed. I loved the way my skin glowed after each use,how it spread, and how thin and easy it was to layer underneath the moisturizer. This is a great antioxidant serum I am happy to have in my routine and would purchase when this out to keep using it. This product was gifted to me in exchange for my honest review.
I've been using the PEPOXIDE Antioxidant Peptide Concentrate and my skin loves it. It's super lightweight, soaks in fast, and leaves my skin feeling smooth and hydrated. After a couple weeks, I noticed a healthy glow and more even tone. No irritation, just results. Definitely a new staple in my routine.
So as someone who is in their thirties, i'm very in tune now with anti aging in any skincare, I can use that can promote that. Im very much familiar with this brand and have been a active user of it for years. Im currently, using several products and the anti-aging lineup and I really feel that they're doing some major benefits to my skin. The serum soaks in my skin very well, doesn't leave it tacky, feeling or oily, and i'm able to wear the moisturizer over it as well without it pilling up and feeling like i'm removing it. It's been a few weeks and I'm definitely going to continue with this because I feel like my skin is looking really good . My skin is much more softer and the lines are starting to become less noticeable.Product was received as part of an educational promotion.
I wasn't sure what to expect with this serum because the smell threw me off a little bit. But it honestly seemed to work really well. After using it for some time I do think it can be very drying so maybe only use this a couple times a week. The serum was nice and went smoothly over my face and seemed to set in just fine. There was a sticky feeling on my hands after. It does seem to work well. But I would take my warning to not over do it at first. The smell isn't good or bad its just different. Not in a good way, it definitely catches you off guard. Thats why I gave it 4/5 stars, it was pretty hard to get past the smell.... it was like old alcohol almost. So maybe you can work on that because it is a great product. I recieved this from beauty tap for my honest feedback
Cosmedix Pepoxide has been a solid addition to my skincare routine!! It feels lightweight, absorbs quickly and doesn't leave my face feeling like it has a sticky layer. It has an orangey scent to it which is refreshing compared to some others “medicinal” smell. I have really noticed my face feels more firm and hydrated and I honestly can say my small wrinkle lines have started to disappear a little! I can definitely see a difference since I've been using this!
I put this on every night as part of my nightly regimen and it doesn't stay wet so no pillow transferring. Another plus? It doesn't make me sweat! My face can still breathe with this on! I will definitely recommend this product to anyone looking for a good serum to add to their routine!
Product was received as part of an educational promotion.
The Cosmedix Elite Pepoxide Serum is a powerhouse in my skincare routine. From the moment you dispense it, the vibrant orangey hue catches your eye�a testament to its rich blend of active ingredients like Astaxanthin, Superoxide Dismutase, and Spin Trap, all renowned for their antioxidant properties . 
The serum boasts a lightweight, fluid texture that glides effortlessly onto the skin, absorbing quickly without any sticky residue. Packaged in a sleek, hygienic pump bottle, it ensures precise application and maintains the product's integrity.
What truly sets Pepoxide apart is its efficacy. The inclusion of Acetyl Hexapeptide-1 works wonders in firming and tightening the skin, reducing the appearance of fine lines and wrinkles . Additionally, ingredients like Rhodiola and Ferulic Acid help soothe the skin and brighten the complexion, leaving it radiant and rejuvenated.  
Incorporating this serum into my daily regimen has noticeably improved my skin's texture and tone. It's a potent blend that delivers visible results, making it a staple in my skincare arsenal.
This is an absolutely amazing product works great it leaves my skin looking so beautiful and young as ever
This serum is something special. The scent is definitely earthy when first applied, but it fades almost instantly, which I actually appreciate - it doesn't compete with anything else I might layer on. The texture is lightweight and sinks in like a dream. It feels like my skin just drinks it up, leaving it smooth and primed for makeup. It layers beautifully without pilling or feeling heavy. Just one pump covers my entire face and it dries down quickly, so I work fast to apply evenly. After using it consistently, I've noticed my skin has a visible glow and looks more even overall. Fine lines seem softer and everything just looks more hydrated and healthy. It's honestly a joy to use every morning. You can tell there are serious ingredients at work here, and the results speak for themselves. This product was provided for promotional purposes in exchange for my honest review.
Cosmedix Pepoxide Antioxidant Peptide Concentrate is a “multivitamin” for your face. I personally think it's a perfect serum that should be on everyone's bathroom counter. It's packed full of so much good stuff that your skin needs and drinks right up. At first there is a slight tackiness to the serum but it absorbs quickly into the skin. It has almost a maple scent to me but that also quickly fades as the products is absorbed. It layers well with all of my other skin care and I haven't noticed any pilling. I have notice that my skin has more of a glow to it and my texture is starting to even out a bit. This is definitely one of those products that I am excited to keep trying. I do feel like over time it will help to soften my fine lines because of now hydrated and smooth it makes my skin feel. I received this product in exchange for my educated review.
I have been using this serum for a couple of weeks , It does seem to moisturize my skin but I wouldn't say it's super moisturizing. I have noticed some improvement in skin tone and there has been some wrinkle reduction and my skin does have a nice glow now, but I am not sure if it is due to this specific product or the fact that I'm using a routine that includes this and others products. This serum is not sticky. It is also not greasy and absorbs nicely, it does not really have a scent.
Cosmedix recommended to use this product after a laser treatment or spa peeling , which I do regularly so I use this serum as a barrier cream, this serum helps to recover my face faster .
I am in my 30s, and starting to see the first signs of aging, from a beautiful outdoor lifestyle. I was attracted to this serum for its purported brightening and evening properties. I used this morning and night as a first step in my skincare routine after washing. The texture is light and watery. It's a gel-like brown liquid that smells like licorice- a little strange at first but I grew to like it, as it reminded me of all of the natural ingredients that go into it.
After two weeks of use, I started to notice subtle changes. My skin felt firmer and was slightly more even toned. Nothing dramatic, but my skin just felt "healthier". I feel like it helped my battered skin barrier and worked well with my natural body chemistry and combination skin.
I wish the results were more dramatic, but I am also confident that this serum works in a gentle way, over time, to improve my skin tone.
This product was provided for promotional purposes in exchange for my honest review
I am loving the Pepoxide Antioxidant Peptide Concentrate. It's packed with 16 antioxidants for protection from harmful free radicals. Plus Acetyl Hexapeptide to help even out skin tone. These are both benefits that I actively seek out in skincare products, so this one ticks all the boxes for me.
The texture is very thin and it absorbs quickly. It makes my skin feel a bit tight, but since it's not the last step of my skincare routine that doesn't matter. I am able to layer the rest of my skincare routine over it with ease, both daytime and nighttime.
This serum is power packed. The product package looks very nice as it comes with a pump dispenser.
It has an amber colour and glides through the face when applied. It goes so well with other product thus very good when layering your skincare products.
I used this product consistently for a week and haven't noticed any noticeable difference on my skin. It didn't brighten me up. It just felt like my skin just remained the same. I think it could take more than a week before I would see any difference. So I'll keep using it longer to see if there's anything. Even though I didn't notice a glow, my skin felt healthier. Can't explain exactly how that feels but it felt clean and healthy. Like it could breathe better if you know what I mean. The product has so much to offer. So I'll just use it longer to see if there's any difference.
This product was provided for promotional purposes in exchange for my honest review
My skin had been feeling a little dull, a little uneven, and frankly, a little tired. I wanted something that could give me that lit-from-within glow while also working behind the scenes to target fine lines and strengthen my skin barrier. Spoiler alert: Pepoxide delivered. This product was provided for promotional purposes in exchange for my honest review.
From the very first pump, I knew this was something special. The texture is everything you want in a serum�lightweight, silky, and quick-absorbing. It glides effortlessly across the skin, leaving zero stickiness or greasy film behind. One pump is genuinely all I need to cover my entire face and neck, which adds to its value. A little goes a long way, and I love that it makes my skincare routine feel efficient and elevated. Plus, it has a soft, refreshing scent that's subtle enough for sensitive noses but still adds a sensory boost that makes the experience feel indulgent.
Within the first few days of using Pepoxide, I noticed my skin looked smoother and brighter. By the end of the first week, my skin tone looked noticeably more even. Some minor redness and dull patches had started to fade, and my face just looked... healthier. There's really no other word for it. It's that fresh, clean, “just had a facial” kind of look�but it's happening from a bottle in my bathroom.
It layers beautifully under every product I've tested with it�SPF, moisturizers, other serums, even makeup. No pilling, no patchiness, no weird reactions. In fact, I'd argue it makes my makeup sit better because my skin is smoother and more hydrated overall.
I use it both morning and night (yes, it's that gentle!), and it fits seamlessly into my routine. It's rare to find a product that works this well without demanding extra steps or changes to your existing regimen.
Pepoxide is packed with antioxidants and peptides�two of my favorite skincare powerhouses. The antioxidants help protect the skin from environmental stressors (think pollution, sun exposure, and free radicals), while the peptides work to firm the skin, reduce the appearance of fine lines, and support long-term skin health.
The combination is like a one-two punch for your skin: protect and repair. That's what makes it so great for both younger skin looking to prevent aging and more mature skin that wants to target existing signs of aging.
It really feels like I'm feeding my skin every time I use it. It's not just skincare�it's skin nutrition.
My skin can be finicky, especially with active ingredients. I've had products that were technically “great” but left me with redness, breakouts, or dryness. Not so with Pepoxide. Even with consistent daily use, I've had zero irritation. No burning, no redness, no purging. It's truly gentle but effective, which is a rare and beautiful thing.
It checks all the boxes�radiance, hydration, anti-aging, smooth texture, compatibility with other products. It's a product that delivers noticeable results while feeling effortless and luxurious to use. The kind of skincare that turns your routine into ritual. And Pepoxide stands out as a quiet achiever�effective, elegant, and absolutely essential. This product was provided for promotional purposes in exchange for my honest review.
I am always looking for a great new product to help my aging skin. As a beauty professional I always want to look my best for my clients, so I was super excited to try out this Cosmedix Pepoxide antioxidant peptide treatment.
The first thing I noticed was the obvious color and scent. I will say that the scent is stronger than I would prefer, and it smells almost medicinal/herbal. The orange/amber color does rub in very easily and left no residue on my skin. However, it definitely felt a little sticky� which I honestly didn't love. My skin though, felt buttery soft using this! I do feel like I've seen a difference in the brightness of my skin and a reduction in fine lines. I would definitely recommend giving this a try if you're on the fence.
I did receive this product for promotional and educational purposes in exchange for my honest review.
I've been using the COSMEDIX Pepoxide Antioxidant Peptide Concentrate for a few weeks now, and I am genuinely impressed. My skin looks noticeably brighter, smoother, and more hydrated. The lightweight, non-greasy texture absorbs beautifully and layers well with the rest of my skincare routine.
What really stands out is the antioxidant protection�it gives my skin a healthy, revitalized glow while helping to reduce redness and signs of fatigue. I love that it's packed with antioxidants and peptides�it feels like I'm feeding my skin exactly what it needs. I've noticed a visible improvement in texture and tone. I've also noticed my complexion looks more even and calm. It's like a daily defense shield against environmental stressors.
If you're looking to boost your skincare routine with a powerful peptide and antioxidant blend, this is it. Worth every penny!
I've been using the CosMedix Pepoxide Antioxidant Peptide Concentrate and� wow. I did not expect to be this surprised by both the consistency and the color! It has such a unique texture�light but rich�and the slightly amber tone gives it a luxurious, potent feel.
I apply it around my eyes at night, and every morning I wake up with visibly more hydrated, smoother skin. It's become a non-negotiable part of my evening routine. Love that it feels powerful but never irritates my sensitive skin.
Highly recommend for anyone looking to boost their skincare with an antioxidant step that actually delivers results.
on all order over $160
within 30 days of purchase
by Aestehticians & Dermatologists
Pepoxide Antioxidant Peptide Concentrate
$97.00